QuickView for gpt;jsessionid=739AC5ED9A277B50091502A3657F7F11;jsessionid=D4E6B1D1F658F37F1C36A0CC6D769EB7;jsessionid=9278BA6684CF60F2914250F4EB474202;jsessionid=80597EC382D4EA1326116328A17D35F8;jsessionid=9CB2464197701D1F29B725135771D373;jsessionid=AADA776DAB12C09CC8D71BA60D203519 (gene)

Gene Symbol:

GPT Homo sapiens

Full name:

glutamic--pyruvic transaminase

Synonyms:

AAT1, ALT1, GPT1, alanine aminotransferase 1, GPT 1, alanine aminotransferase, glutamate pyruvate transaminase 1, glutamic--pyruvic transaminase 1, glutamic-alanine transaminase 1, glutamic-pyruvate transaminase (alanine aminotransferase)

Genomic Location:

Chr 8: 145700231-145703357

Description:

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels o...

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This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Schizosaccharomyces pombe ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6

Cytogenetic Map:

8q24.3

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