QuickView for mGluR;jsessionid=B0E5D0425DD3D33E2058C67771A59DB9;jsessionid=408B61C8501848A3735D8D0E0C6896DA (gene)

Gene Symbol:

GRM8 Homo sapiens

Full name:

glutamate metabotropic receptor 8

Synonyms:

GLUR8, GPRC1H, MGLUR8, mGlu8, metabotropic glutamate receptor 8, glutamate receptor, metabotropic 8

Genomic Location:

Chr 7: 125865895-126670548

Description:

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G pr...

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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CTTGTAT_MIR381 ,  TAL1ALPHAE47_01 ,  OCT1_04 ,  YTATTTTNR_MEF2_02 ,  NKX3A_01 ,  WGTTNNNNNAAA_UNKNOWN ,  MEIS1BHOXA9_01 ,  TGACCTY_ERR1_Q2 ,  WTGAAAT_UNKNOWN ,  RGAANNTTC_HSF1_01 ,  CAGGTG_E12_Q6 ,  TAATAAT_MIR126 ,  HSF_Q6 ,  YCATTAA_UNKNOWN ,  MEIS1AHOXA9_01 ,  TAATTA_CHX10_01 ,  CART1_01 ,  GTGTCAA_MIR514 ,  TACAATC_MIR508 ,  ER_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

7q31.33

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