QuickView for megalin;jsessionid=FF21DB813850C4FFA087C6E306443547;jsessionid=E57356A47897D3D134349FE7D42F3E33 (gene)
- Gene Symbol:
- Lrp2
Rattus norvegicus - Full name:
- LDL receptor related protein 2
- Synonyms:
- low-density lipoprotein receptor-related protein 2, LRP-2, glycoprotein 330, gp330, low density lipoprotein-related protein 2, megalin
- Genomic Location:
- Chr 3: 51563764-51724478
- Description:
-
receptor for low density lipoprotein and a major kidney glomerular antigen for rat Heymann nephritis
- Orthologs:
- Homo sapiens , Mus musculus , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio , D. melanogaster
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
low-density lipoprotein particle receptor binding | cation binding | hormone receptor binding | hemoglobin binding | protein-containing complex binding | lipoprotein particle receptor binding | SH3 domain binding | signaling receptor binding | chaperone binding | protein domain specific binding | signaling receptor activity | nuclear hormone receptor binding | ion binding | hormone binding | protein binding | transcription factor binding | calcium ion binding | PDZ domain binding | steroid hormone receptor binding | drug binding | metal ion binding
GO Biological Process
response to extracellular stimulus | brain development | response to radiation | cell morphogenesis | ventricular cardiac muscle tissue morphogenesis | response to nutrient levels | positive regulation of cellular component organization | regulation of neurogenesis | neuron projection morphogenesis | developmental process involved in reproduction | muscle tissue development | regulation of cell development | regulation of localization | neuron projection arborization | morphogenesis of an epithelium | gonad development | hormone secretion | response to X-ray | establishment of localization | negative regulation of BMP signaling pathway | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | nervous system development | response to drug | cell part morphogenesis | neurogenesis | generation of neurons | sensory perception of mechanical stimulus | intracellular transport | negative regulation of proteolysis | coronary artery morphogenesis | blood vessel morphogenesis | pattern specification process | cellular process | secretion | localization | cell projection morphogenesis | epithelial tube morphogenesis | protein transport | heart morphogenesis | negative regulation of signaling | metal ion transport | neuron development | reproductive system development | dicarboxylic acid transport | anion transport | macromolecule localization | regulation of proteolysis | establishment of localization in cell | negative regulation of cellular metabolic process | folic acid transport | tissue development | regulation of cell differentiation | muscle structure development | regeneration | regulation of cellular process | regulation of metabolic process | epithelium development | coronary vasculature morphogenesis | cellular component organization | development of primary sexual characteristics | head development | muscle organ morphogenesis | response to stimulus | vasculature development | embryonic epithelial tube formation | endosomal transport | regulation of oligodendrocyte progenitor proliferation | regulation of cell proliferation | tube morphogenesis | cardiac muscle tissue development | muscle tissue morphogenesis | epithelial tube formation | reproduction | cellular localization | secretion by cell | cardiovascular system development | cardiac ventricle morphogenesis | heart formation | positive regulation of gliogenesis | regulation of protein transport | response to vitamin D | negative regulation of metabolic process | regulation of peptide transport | embryo development | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | carboxylic acid transmembrane transport | blood vessel development | folate transmembrane transport | regulation of nucleic acid-templated transcription | ventricular compact myocardium morphogenesis | system development | reproductive process | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of BMP signaling pathway | endocytic hemoglobin import | regulation of catalytic activity | vitamin transport | vagina development | regulation of hormone levels | ion transmembrane transport | transcytosis | negative regulation of peptidase activity | artery development | regulation of gene expression | neural tube closure | outflow tract morphogenesis | organic substance transport | response to lipid | nervous system process | coronary vasculature development | animal organ morphogenesis | specification of animal organ identity | regulation of nitrogen compound metabolic process | small molecule metabolic process | vitamin transmembrane transport | peptide transport | negative regulation of cellular response to growth factor stimulus | neural tube formation | vesicle-mediated transport | regulation of transcription by RNA polymerase II | response to nutrient | organic acid transport | protein localization to organelle | positive regulation of cell differentiation | cell proliferation | neural tube development | regulation of cellular protein metabolic process | organic anion transport | cardiac septum morphogenesis | protein import | chordate embryonic development | animal organ formation | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | female genitalia development | sensory perception of sound | regulation of protein metabolic process | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | positive regulation of transport | genitalia development | response to retinoic acid | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | neuron differentiation | development of primary male sexual characteristics | ventricular septum development | regulation of establishment of protein localization | regionalization | cardiac ventricle development | response to organic substance | tissue morphogenesis | artery morphogenesis | vitamin metabolic process | male sex differentiation | import into cell | anion transmembrane transport | ventricular cardiac muscle tissue development | establishment of protein localization to organelle | anatomical structure development | organic acid transmembrane transport | cofactor transport | positive regulation of neurogenesis | aorta development | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | positive regulation of cell development | regulation of RNA biosynthetic process | male gonad development | cellular protein localization | amide transport | regulation of vesicle-mediated transport | endocytosis | heart field specification | morphogenesis of embryonic epithelium | hormone transport | neuron projection development | positive regulation of lipoprotein transport | response to vitamin | animal organ development | forebrain development | negative regulation of cellular protein metabolic process | folate import across plasma membrane | establishment of protein localization | drug transport | positive regulation of protein transport | pulmonary artery morphogenesis | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | sensory perception | regulation of cell communication | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | positive regulation of oligodendrocyte progenitor proliferation | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | regulation of endocytosis | protein localization | drug transmembrane transport | carboxylic acid transport | anatomical structure morphogenesis | regulation of endopeptidase activity | cation transport | cellular macromolecule localization | reproductive structure development | regulation of nervous system development | regulation of developmental process | heme transport | receptor-mediated endocytosis | positive regulation of neural precursor cell proliferation | developmental process | cardiac septum development | tube development | regulation of transport | signal release | tube closure | secondary heart field specification | cardiac chamber development | negative regulation of hydrolase activity | tube formation | central nervous system development | ion transport | female sex differentiation | regulation of protein localization | sex differentiation | circulatory system development | aging | positive regulation of endocytosis | regulation of cellular component organization | response to ionizing radiation | muscle organ development | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | animal organ regeneration | outflow tract septum morphogenesis | multicellular organismal process
GO Cellular Component
brush border | integral component of membrane | dendrite | intracellular membrane-bounded organelle | apical plasma membrane | neuron projection | somatodendritic compartment | cell projection membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | receptor complex | endoplasmic reticulum | membrane microdomain | brush border membrane | dendritic tree | apical part of cell | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | plasma membrane | membrane raft | vesicle | clathrin-coated pit | endosome | extracellular region | membrane-bounded organelle | endosome lumen | organelle | extracellular space | cell periphery | axon | membrane-enclosed lumen | intracellular vesicle | cell surface | endocytic vesicle | intracellular | membrane
