QuickView for orexin;jsessionid=4A70FE8FD0AD9259A4B85084639245C6;jsessionid=740B13492D8A478611854DE6492D24B2 (gene)

Gene Symbol:

HCRT Homo sapiens

Full name:

hypocretin neuropeptide precursor

Synonyms:

NRCLP1, OX, PPOX, orexin, hypocretin (orexin) neuropeptide, prepro-orexin

Genomic Location:

Chr 17: 37589604-37590996

Description:

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role ...

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This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_01 ,  GATA3_01 ,  SMAD3_Q6 ,  RNCTGNYNRNCTGNY_UNKNOWN ,  TATAAA_TATA_01 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  WTTGKCTG_UNKNOWN ,  CTTTGT_LEF1_Q2

Cytogenetic Map:

17q21.2

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