QuickView for pC2;jsessionid=9D2B93FA8217C790F4E6AF5C0BEFCA6A;jsessionid=DD018DE0FF77F774AC0267CCDE83E519 (gene)

Gene Symbol:

PCSK2 Homo sapiens

Full name:

proprotein convertase subtilisin/kexin type 2

Synonyms:

NEC 2, NEC-2, NEC2, PC2, SPC2, neuroendocrine convertase 2, KEX2-like endoprotease 2, prohormone convertase 2

Genomic Location:

Chr 20: 17155631-17413223

Description:

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in...

View Full Description

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBPA_01 ,  CATTGTYY_SOX9_B1 ,  E4BP4_01 ,  NKX3A_01 ,  GCANCTGNY_MYOD_Q6 ,  NGFIC_01 ,  GGAMTNNNNNTCCY_UNKNOWN ,  MEIS1BHOXA9_01 ,  NFKAPPAB_01 ,  TTAYRTAA_E4BP4_01 ,  TGACCTY_ERR1_Q2 ,  NFKAPPAB65_01 ,  WTGAAAT_UNKNOWN ,  NRSF_01 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  STAT_Q6 ,  CEBPDELTA_Q6 ,  CATTTCA_MIR203 ,  GTGACGY_E4F1_Q6 ,  CDX2_Q5 ,  STAT5B_01 ,  CACCAGC_MIR138 ,  LHX3_01 ,  EGR_Q6 ,  TGCGCANK_UNKNOWN ,  CREB_02 ,  ACCAAAG_MIR9 ,  CREBP1_01 ,  NKX61_01 ,  TAATAAT_MIR126 ,  SPZ1_01 ,  TGTTTGY_HNF3_Q6 ,  SOX5_01 ,  RNGTGGGC_UNKNOWN ,  HLF_01 ,  OCT1_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AFP1_Q6 ,  GTGGGTGK_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  CREL_01 ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  EGR1_01 ,  NFKB_Q6_01 ,  TGACATY_UNKNOWN ,  NFKB_Q6 ,  NFKB_C ,  GGGNNTTTCC_NFKB_Q6_01 ,  GGGTGGRR_PAX4_03 ,  STAT5A_02 ,  TCF11_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-203

Cytogenetic Map:

20p12.1

search → result