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QuickView for pannexin-1;jsessionid=C70ABE6EC5B4B05453F06299A91FA925 (gene)


Gene Symbol:
Panx1 Rattus norvegicus Rattus norvegicus
Full name:
Pannexin 1
Synonyms:
px1, pannexin-1
Genomic Location:
Chr 8: 11809752-11849392
Description:
The protein encoded by this gene is a plasma membrane protein that is a structural component of gap junctions. The encoded protein acts as a homodimer or as a heterodimer with other isoforms or proteins. Two additional variants have been found, and the isoforms expressed from them are found in the cytoplasm. It is thought that these two isoforms co...
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Danio rerio Pan troglodytes Bos taurus Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:





GO Molecular Function

actin binding | actin filament binding | passive transmembrane transporter activity | enzyme binding | gap junction hemi-channel activity | protein-containing complex binding | transmembrane transporter activity | signaling receptor binding | gap junction channel activity | ion channel binding | cytoskeletal protein binding | leak channel activity | cation transmembrane transporter activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | protein heterodimerization activity | scaffold protein binding | protein binding | wide pore channel activity | metal ion transmembrane transporter activity | protein dimerization activity | cation channel activity | inorganic cation transmembrane transporter activity | channel activity | protease binding | calcium channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

response to extracellular stimulus | regulation of interleukin-1 beta production | protein hexamerization | response to nutrient levels | response to ATP | regulation of localization | establishment of localization | response to drug | positive regulation of interleukin-1 beta secretion | positive regulation of protein secretion | response to organophosphorus | cellular process | localization | passive transmembrane transporter activity | metal ion transport | gap junction hemi-channel activity | regulation of cellular process | transmembrane transporter activity | cellular component organization | regulation of peptide secretion | response to stimulus | positive regulation of interleukin-1 beta production | response to stress | gap junction channel activity | divalent metal ion transport | positive regulation of cytokine secretion | response to ischemia | regulation of protein transport | cellular component assembly | regulation of peptide transport | cell-cell signaling | positive regulation of peptide secretion | response to nitrogen compound | calcium ion transmembrane transport | response to purine-containing compound | protein complex oligomerization | ion transmembrane transport | leak channel activity | positive regulation of interleukin-1 alpha production | positive regulation of secretion | cation transmembrane transporter activity | response to nutrient | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | positive regulation of interleukin-1 secretion | regulation of interleukin-1 production | cell communication | positive regulation of interleukin-1 production | positive regulation of establishment of protein localization | positive regulation of transport | regulation of cytokine secretion | cation transmembrane transport | protein-containing complex assembly | regulation of establishment of protein localization | positive regulation of interleukin-1 alpha secretion | response to organic substance | wide pore channel activity | metal ion transmembrane transporter activity | regulation of interleukin-1 beta secretion | calcium ion transport | regulation of secretion | regulation of protein secretion | inorganic cation transmembrane transport | positive regulation of cytokine production | positive regulation of protein transport | cation channel activity | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | response to organic cyclic compound | regulation of cytokine production | cation transport | channel activity | calcium channel activity | regulation of transport | response to organonitrogen compound | ion channel activity | ion transport | regulation of protein localization | substrate-specific channel activity

GO Cellular Component

bleb | integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | cell-cell junction | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | endomembrane system | endoplasmic reticulum membrane | plasma membrane | gap junction | membrane-bounded organelle | organelle | cell periphery | intracellular | cell junction | membrane