QuickView for pyrin;jsessionid=4F7349B9F19EE3CB94ACCD79B210F4DD;jsessionid=5C955A3A21B6E750A59296E8C0C237E0 (gene)
- Gene Symbol:
- MEFV
Homo sapiens - Full name:
- MEFV, pyrin innate immunity regulator
- Synonyms:
- FMF, MEF, TRIM20, pyrin, Mediterranean fever, marenostrin
- Genomic Location:
- Chr 16: 3232029-3246628
- Description:
-
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
16p13.3
GO Molecular Function
actin binding | cation binding | cytoskeletal protein binding | identical protein binding | ion binding | protein binding | zinc ion binding | transition metal ion binding | metal ion binding
GO Biological Process
regulation of interleukin-1 beta production | regulation of cysteine-type endopeptidase activity | negative regulation of cytokine production involved in inflammatory response | response to cytokine | regulation of autophagy | negative regulation of cellular process | defense response | negative regulation of inflammatory response | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | negative regulation of interleukin-1 production | regulation of metabolic process | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | response to stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | positive regulation of cysteine-type endopeptidase activity | positive regulation of proteolysis | regulation of NLRP3 inflammasome complex assembly | regulation of peptidase activity | regulation of catalytic activity | negative regulation of chemokine production | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | positive regulation of hydrolase activity | negative regulation of macrophage inflammatory protein 1 alpha production | negative regulation of interleukin-12 production | regulation of cytokine production involved in inflammatory response | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | regulation of interleukin-1 production | regulation of cellular metabolic process | inflammatory response | regulation of protein metabolic process | positive regulation of molecular function | response to organic substance | immune response | negative regulation of protein complex assembly | positive regulation of autophagy | response to interferon-gamma | regulation of cytokine production | regulation of endopeptidase activity | negative regulation of interleukin-1 beta production | regulation of chemokine production | negative regulation of NLRP3 inflammasome complex assembly | innate immune response | positive regulation of metabolic process | immune system process | regulation of inflammatory response | regulation of cellular component organization
GO Cellular Component
supramolecular fiber | intracellular membrane-bounded organelle | ruffle | microtubule associated complex | cytoplasmic vesicle | cell | lamellipodium | microtubule | cytoplasm | intracellular organelle | protein-containing complex | cell projection | cell leading edge | vacuole | vesicle | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular vesicle | cytoskeleton | intracellular | autophagosome | supramolecular complex
