QuickView for sp56;jsessionid=0F760FC152629B5F94A42EBB12529867;jsessionid=6CABB4B33B3AD15A5F62F7BC561679A7 (gene)

Gene Symbol:

PRSS8 Homo sapiens

Full name:

protease, serine 8

Synonyms:

CAP1, PROSTASIN, prostasin, channel-activating protease 1, serine protease 8

Genomic Location:

Chr 16: 31050255-31054652

Description:

This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes fou...

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This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGAGGRR_MAZ_Q6 ,  CTGAGCC_MIR24

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24

Cytogenetic Map:

16p11.2

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