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QuickView for zonulin;jsessionid=02FF1AFB75DD86BAC1E6D9C61A78D26D;jsessionid=2158C74AA878EE51CA5E379A51F8F15A (gene)


Gene Symbol:
Hp Mus musculus Mus musculus
Full name:
haptoglobin
Synonyms:
HP-1, preHP2, haptoglobin, zonulin
Genomic Location:
Chr 8: 112099028-112102963
Description:
This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
NM_017370
NM_001329965
Protein Names
Q3UBS3
Q61646



GO Molecular Function

antioxidant activity | hemoglobin binding | hydrolase activity | catalytic activity | serine hydrolase activity | identical protein binding | protein binding | protein homodimerization activity | protein dimerization activity | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase activity

GO Biological Process

Notch signaling pathway | proteolysis | defense response to other organism | negative regulation of cellular process | defense response | response to drug | response to antibiotic | cellular process | cellular detoxification | antioxidant activity | negative regulation of hydrogen peroxide catabolic process | response to inorganic substance | negative regulation of cellular metabolic process | response to hydrogen peroxide | regulation of cellular process | regulation of metabolic process | hepaticobiliary system development | response to stimulus | response to stress | cellular response to toxic substance | negative regulation of metabolic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | multicellular organism development | negative regulation of catalytic activity | regulation of catalytic activity | liver development | response to oxidative stress | acute-phase response | response to toxic substance | regulation of hydrogen peroxide metabolic process | response to bacterium | cell communication | regulation of cellular metabolic process | inflammatory response | defense response to bacterium | protein metabolic process | response to organic substance | gland development | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cellular oxidant detoxification | negative regulation of hydrogen peroxide metabolic process | positive regulation of cell death | organic substance metabolic process | animal organ development | response to reactive oxygen species | serine-type endopeptidase activity | serine-type peptidase activity | negative regulation of molecular function | signaling | regulation of oxidoreductase activity | endopeptidase activity | response to biotic stimulus | developmental process | regulation of reactive oxygen species metabolic process | detoxification | negative regulation of oxidoreductase activity | acute inflammatory response | immune system process | peptidase activity | regulation of cell death | response to other organism | negative regulation of reactive oxygen species metabolic process | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | haptoglobin-hemoglobin complex | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | protein-containing complex | endomembrane system | extracellular region | membrane-bounded organelle | organelle | extracellular space | blood microparticle | intracellular