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4-hydroxytamoxifen
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
LINC01588
KRT13
IGFBP4
SDK2
SLC47A1
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Pathway Enrichment
Most Correlated Biogroups
GOZGIT_ESR1_TARGETS_DN
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN
vesicle
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP
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Curated Studies
Most Correlated Studies
Breast cancer MCF-7 cells treated with selective estrogen receptor modulators
MCF7 breast cancer cells treated with tamoxifen metabolites in the presence or absence of estrogen.
Parathyroid adenomas treated with diarylpropionitrile or 4-hydroxytamoxifen
MCF 7 breast cancer cells treated with 4-hydroxytamoxifen and siRNA against ESR1 or RAR-alpha
MCF7 cell profiles of tamoxifen-resistant and sensitive subclones exposed to tamoxifen and estrogen
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Literature
Most Relevant Literature
The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene…
Dissimilar action of tamoxifen and 4-hydroxytamoxifen on phosphatidylcholine model membranes.
Dose-dependent effects of Hedyotis diffusa extract on the pharmacokinetics of tamoxifen, 4-hydroxyta…
Design and optimization of oestrogen receptor PROTACs based on 4-hydroxytamoxifen.
5-Oxoproline Enhances 4-Hydroxytamoxifen-induced Cytotoxicity by Increasing Oxidative Stress in MCF-…
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Clinical Trials
Most Relevant Clinical Trials
Effect of 4-Hydroxytamoxifen Gel on Breast Density, Salivary Sex Steroids, and Quality of Life in Pr…
Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through the Breast Skin to Contro…
Trial of 4-OHT Gel in Women Aimed at Reducing Dense Breast Tissue
Therapeutic Dose Monitoring (TDM) of Tamoxifen
Oral Tamoxifen vs. TamGel vs. Control in Women With Atypical Hyperplasia or Lobular Carcinoma In Sit…
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