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4-methylpyrazole
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
CYP51A1
HMGCS1
PPP2CA
FGF9
NME1
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Pathway Enrichment
Most Correlated Biogroups
cytosol
cell periphery
nucleoplasm
response to organic substance
regulation of nitrogen compound metabolic process
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Curated Studies
Most Correlated Studies
Drug Matrix In Vivo Toxicogenomic Study - Rat Liver [Codelink]
Drug target sets for approved compounds
Liver Pharmacology and Xenobiotic Response Repertoire
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
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Literature
Most Relevant Literature
Kinetics of fomepizole in pregnant rats.
4-Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats.
Fomepizole for severe disulfiram-ethanol reactions.
Cost of hemodialysis versus fomepizole-only for treatment of ethylene glycol intoxication.
Effect of 4-methylpyrazole on antioxidant enzyme status and lipid peroxidation in the liver of rats …
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Clinical Trials
Most Relevant Clinical Trials
Phase 1 Pilot Study of 4-MP to Treat Stargardt Macular Dystrophy
Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Alte…
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Perfor…
A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placeb…
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