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CTLA-4-Ig
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
CD80
CD86
HIST1H3G
MYH2
HIST1H2AJ
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Pathway Enrichment
Most Correlated Biogroups
TTTNNANAGCYR_UNKNOWN
REACTOME_IMMUNE_SYSTEM
GAL_LEUKEMIC_STEM_CELL_DN
immune response
positive regulation of immune system process
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Curated Studies
Most Correlated Studies
CD4-positive T cells and antigen presenting cells from OVA TCR mice treated with abatacept
T-cells expression after treatment with leukocyte costimulatory blockade antibodies
Drug target sets for approved compounds
Germinal B cells from spleen of systemic lupus erythematosus mice treated with CTLA4Ig & anti-CD40L
Whole blood of rheumatoid arthritis patients treated with abatacept
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Literature
Most Relevant Literature
Rapid response to abatacept in treatment-resistant pansclerotic morphoea.
Improvement in Disease Activity in Refractory Juvenile Dermatomyositis Following Abatacept Therapy.
Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Doubl…
Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse even…
A review on applications of abatacept in systemic rheumatic diseases.
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Clinical Trials
Most Relevant Clinical Trials
Clinical Study of Recombinant Humanized CTLA-4-FC Fusion Protein Injection in Healthy Subjects
Intravenous CTLA4-lg Treatment in Recent Onset Type 1 Diabetes Mellitus
Rheumatoid Arthritis Treatment After First Anti-TNF INvestiGation
Phase IIIB Subcutaneous Missed Dose Study
A Phase 1B/2 Study of RP1 in Solid Organ Transplant Patients With Advanced Cutaneous Malignancies
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