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Geldanamycin
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
XIST
CRIP1
HSPA1A
HSPA6
SERPINA3
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Pathway Enrichment
Most Correlated Biogroups
organic cyclic compound binding
heterocyclic compound binding
regulation of nitrogen compound metabolic process
organic cyclic compound metabolic process
heterocycle metabolic process
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Curated Studies
Most Correlated Studies
Prostate cancer LnCaP cells treated with bicalutamide, 17-AAG or SAHA
Diffuse Large B-Cell Lymphoma OCI-LY3 cells time-course/dose response treatment with 14 drug panel
B cells from chronic lymphocytic leukemia patients treated with Hsp90 inhibitor 17-DMAG
PC3 cells treated with Wee1 inhibitor II and 17AAG
A2780 and MCF7 cancer cell lines treated with CDK, HSP90, and topoisomerase inhibitors
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Literature
Most Relevant Literature
Discovery of Bioactive Metabolites by Acidic Stress to a Geldanamycin Producer, Streptomyces samsune…
Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic …
Molecular determinants of the response of cancer cells towards geldanamycin and its derivatives.
Total Synthesis of Geldanamycin.
Geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting…
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Clinical Trials
Most Relevant Clinical Trials
Geldanamycin Analogue in Treating Patients With Advanced Cancer
Geldanamycin Analogue in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma
17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in Treating Patients With an Advanced …
Dose Escalation of IPI-493 in Hematologic Malignancies
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