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Merlin
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Summary
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Body Atlas
Most Correlated Tissues
Smooth muscle
Conjunctiva
Skeletal muscle psoas
Substantia nigra reticulata
Hippocampus
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Disease Atlas
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Curated Studies
Most Correlated Studies
Transcriptional control by Merlin in cancer cell lines
Schwannoma gene expression profiles in response to expression of mutant Nf2 and depletion of DCAF1
Pleural mesothelioma Meso-33 cells with DCAF1, YAP1, or TAZ siRNA knockdowns
Forebrains, midbrains and dorsal telencephalons with YAP1[S127A] overexpression or NF2-deletions
Chronic myelogenous leukemia K562 cells overexpressing novel SPI1 isoform (Pu.2)
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Literature
Most Relevant Literature
Re-evaluation of missense variant classifications in NF2.
Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppresso…
Origins of biallelic inactivation of NF2 in neurofibromatosis type 2.
Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma.
LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway.
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Clinical Trials
Most Relevant Clinical Trials
Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Bi…
Electronic Patient Notification of Remote ICD Data: Impact of Patient Engagement on Outcomes in the …
Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold Sor…
Clinical Study of Merlin's DiVeRt - Vascular Reconstruction Device and Delivery System
Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores
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