QuickView for NPL4 (gene)

1. Cdc48Ufd1/Npl4 segregase removes mislocalized centromeric histone H3 variant CENP-A from non-centrom…
2. Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.
3. Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase.
4. Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells.
5. The Cdc48 N-terminal domain has a molecular switch that mediates the Npl4-Ufd1-Cdc48 complex formati…

There were no clinical trials for NPL4