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Nonsense codons
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Curated Studies
Most Correlated Studies
Nonsense-mediated mRNA decay-inhibited LCLs from families predisposed to breast cancer
Colorectal cancer HCT116 cells treated with bafilomycin A1
Cervical carcinoma HeLa cells with shRNA knockdown and rescue of UPF1, SMG6, and SMG7 target genes
Colorectal cancer HCT 116 cells with CRISPR/Cas9-mediated ABCE1 knockout
Lymphoblastoid B-Cell lines from patients with mutations in UPF3B
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Most Relevant Literature
Allele-specific therapy: suppression of nonsense mutations by readthrough inducers].
When a ribosome encounters a premature termination codon.
Read-through therapy for mitochondrial DNA nonsense mutations.
Single nucleotide polymorphisms of Helicobacter pylori dupA that lead to premature stop codons.
Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense…
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Most Relevant Clinical Trials
Ataluren for Nonsense Mutation Methylmalonic Acidemia
Phase 3 Study of Ataluren in Patients With Nonsense Mutation Duchenne Muscular Dystrophy
Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Poly…
Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Poly…
Study of Ataluren (PTC124®) in Nonambulatory Patients With Nonsense-Mutation-Mediated Duchenne/Becke…
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