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PLX4720
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Summary
General Info
Genetic Markers
Most Correlated Genes
SPRY4
DUSP6
UCN2
HS3ST1
BMF
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Pathway Enrichment
Most Correlated Biogroups
regulation of nitrogen compound metabolic process
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY
KOBAYASHI_EGFR_SIGNALING_24HR_DN
CHICAS_RB1_TARGETS_SENESCENT
LEE_BMP2_TARGETS_UP
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Curated Studies
Most Correlated Studies
Colon cancer cell lines with acquired resistance to BRAF inhibitor PLX4720 and parental lines
Apollon knockdown in a melanoma cell line treated with fotemustine, PLX4720 or PD0325901
Melanoma-associated fibroblasts treated with PLX4720
Melanoma Me13 cells treated with MEK1/2, PI3K/mTOR, mTOR, and BRAF V600E inhibitors
Lung adenocarcinoma cells with YAP1 shRNA and treated with MEK or BRAF inhibitor
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Literature
Most Relevant Literature
Downregulation of lncRNA TSLNC8 promotes melanoma resistance to BRAF inhibitor PLX4720 through bindi…
BRAF paradox breakers PLX8394, PLX7904 are more effective against BRAFV600Ε CRC cells compared with …
A Combinatorial Strategy for Targeting BRAF V600E-Mutant Cancers with BRAFV600E Inhibitor (PLX4720) …
The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a…
ROS-mediated SRMS activation confers platinum resistance in ovarian cancer.
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Clinical Trials
Most Relevant Clinical Trials
Biomarker Study of PDR001 in Combination With MCS110 in Gastric Cancer
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