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QuickView for PLX4720 (compound)


Genetic Markers

Most Correlated Genes

  1. SPRY4
  2. DUSP6
  3. GPM6A
  4. HS3ST1
  5. UCN2
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Pathway Enrichment

Most Correlated Biogroups

  1. regulation of nitrogen compound metabolic process
  2. cytosol
  3. organic cyclic compound binding
  4. heterocyclic compound binding
  5. nucleoplasm
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Curated Studies

Most Correlated Studies

  1. Melanoma A375 cells (BRAF V600E) with SOX10 ko or SOX10-deficient BRAFi + MEKi resistant cells
  2. Melanoma A-375 clonal cells with acquired PLX 4720 resistant and MYC shRNA knockdown
  3. Melanoma-associated fibroblasts treated with PLX4720
  4. Apollon knockdown in a melanoma cell line treated with fotemustine, PLX4720 or PD0325901
  5. Colon cancer cell lines with acquired resistance to BRAF inhibitor PLX4720 and parental lines
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Literature

Most Relevant Literature

  1. Downregulation of lncRNA TSLNC8 promotes melanoma resistance to BRAF inhibitor PLX4720 through bindi…
  2. BRAF paradox breakers PLX8394, PLX7904 are more effective against BRAFV600Ε CRC cells compared with …
  3. A Combinatorial Strategy for Targeting BRAF V600E-Mutant Cancers with BRAFV600E Inhibitor (PLX4720) …
  4. The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a…
  5. SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cel…
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Clinical Trials

Most Relevant Clinical Trials

  1. Biomarker Study of PDR001 in Combination With MCS110 in Gastric Cancer
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