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UGT1A1
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NextBio Summary
General Info
Body Atlas
Most Correlated Tissues
Kidney
Liver
Kidney cortex
Bladder
Ileum mucosa
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Disease Atlas
Most Correlated Diseases
Gilbert's syndrome
Porphyria
Hepatocellular dysplasia
Tobacco use and exposure (clinical finding)
Cystic disease of kidney
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Pharmaco Atlas
Most Correlated Compounds
andrographolide
Emodin
fipronil
imperatorin
polydextrose
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Knockdown Atlas
Most Correlated Gene Perturbations
CYP26B1
NSD3
LEF1
Aox4
TOX
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Curated Studies
Most Correlated Studies
Colorectal cancer DLD-1 cells with SOX9 or RBM8A(Y14) siRNA knockdown
Acute myeloid leukemia MLL-AF9 NRAS(G12D) cells with NSD3 shRNA, CHD8shRNA or CHD8 sgRNA knockdown
Livers of one-day-old male rats born to mothers on low protein diet with or without extra folic acid
Lung tumors from 293 patients with clinical outcome
A Genome-wide association study of Circulating cell-free DNA concentration - Jylhava et al
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Literature
Most Relevant Literature
Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment…
A case report of a novel 22 bp duplication within exon 1 of the UGT1A1 in a Sudanese infant with Cri…
Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar synd…
Pazopanib-Induced Liver Toxicity in Patients With Metastatic Renal Cell Carcinoma: Effect of UGT1A1 …
Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal ca…
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Clinical Trials
Most Relevant Clinical Trials
An Observational Study of CPT-11 Plus Platinum Analogues Regimens and UGT1A1 Genotypes in Solid Tumo…
Establish the PK of Belinostat in Patients With Wild-type, Heterozygous, and Homozygous UGT1A1*28 Ge…
High-dose FOLFIRI in Advanced Colorectal Cancer Patients With Wild-type UGT1A1*6 and *28
An Observational Study of CPT-11 Based Regimens and UGT1A1 Genotypes in Metastatic Colorectal Cancer…
Pharmacokinetic Study of CPT-11, Raltegravir and Midazolam With Characterisation of UGT1A1 Genotype
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