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QuickView for UGT1A1 (gene)


Body Atlas

Most Correlated Tissues

  1. Kidney
  2. Liver
  3. Kidney cortex
  4. Bladder
  5. Ileum mucosa
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Disease Atlas

Most Correlated Diseases

  1. Gilbert's syndrome
  2. Porphyria
  3. Hepatocellular dysplasia
  4. Bilirubin level - finding
  5. Tobacco use and exposure (clinical finding)
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Pharmaco Atlas

Most Correlated Compounds

  1. andrographolide
  2. fipronil
  3. Emodin
  4. imperatorin
  5. Nifedipine
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. CYP26B1
  2. NSD3
  3. LEF1
  4. Aox4
  5. TOX
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment…
  2. Correlations of UGT1A1 gene polymorphisms with onset and prognosis of non-small cell lung cancer.
  3. Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar synd…
  4. Association of UGT1A1*6 polymorphism with irinotecan-based chemotherapy reaction in colorectal cance…
  5. Pazopanib-Induced Liver Toxicity in Patients With Metastatic Renal Cell Carcinoma: Effect of UGT1A1 …
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Clinical Trials

Most Relevant Clinical Trials

  1. An Observational Study of CPT-11 Plus Platinum Analogues Regimens and UGT1A1 Genotypes in Solid Tumo…
  2. Establish the PK of Belinostat in Patients With Wild-type, Heterozygous, and Homozygous UGT1A1*28 Ge…
  3. High-dose FOLFIRI in Advanced Colorectal Cancer Patients With Wild-type UGT1A1*6 and *28
  4. An Observational Study of CPT-11 Based Regimens and UGT1A1 Genotypes in Metastatic Colorectal Cancer…
  5. Pharmacokinetic Study of CPT-11, Raltegravir and Midazolam With Characterisation of UGT1A1 Genotype
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