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Werner syndrome
(gene)
Summary
General Info
Body Atlas
Most Correlated Tissues
Granulocyte-macrophage progenitor cell of bone marrow
Hematopoietic stem cell of bone marrow
Dendritic (plasmacytoid) cell
T Lymphocyte (regulatory) of peripheral blood
Basophil of peripheral blood
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Curated Studies
Most Correlated Studies
OMIM - Congenital disorder
Fibroblast gene expression from Werner, Bloom, and Rothmund-Thomson syndrome Coriell strains
Targeted gene correction of LMNA mutations in patient-specific iPSCs
Mouse Phenotypes - Multiple malformation syndrome with senile-like appearance
Transcription profiling of liver from wild type or Ercc1 mutant mice
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Literature
Most Relevant Literature
Combination of untargeted and targeted proteomics for secretome analysis of L-WRN cells.
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplex…
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA s…
A homozygous missense variant in the WRN gene segregating in a family with progressive pulmonary fai…
The WRN helicase: resolving a new target in microsatellite unstable cancers.
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Clinical Trials
Most Relevant Clinical Trials
Phase 2, Open-Label Study to Evaluate the Safety and Tolerability of Progerinin in Werner Syndrome
Descriptive Study of Recombinant Human Insulin-Like Growth Factor for Osteoporosis in Werner's Syndr…
Biomarkers in Primary Sjögren's Syndrome
Analysis of Frailty Syndrome Within the Framework of the Innovation Fund Project PRÄP-GO (ANA-PRÄP-G…
Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation
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