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QuickView for Z-Leu-Leu-Leu-al (compound)


Genetic Markers

Most Correlated Genes

  1. HMOX1
  2. SLC7A11
  3. GADD45A
  4. ATF3
  5. HSPA1A
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Pathway Enrichment

Most Correlated Biogroups

  1. BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP
  2. BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN
  3. GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
  4. organic cyclic compound metabolic process
  5. heterocycle metabolic process
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Curated Studies

Most Correlated Studies

  1. Embryonic fibroblasts with CHOP or ATF5 perturbations
  2. Heat shock response induced by both elevated temperature and a proteasome inhibitor
  3. Broad Connectivity Map (CMAP 2.0) compound database
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Literature

Most Relevant Literature

  1. Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-l…
  2. Centrosomal aggregates and Golgi fragmentation disrupt vesicular trafficking of DAT.
  3. c-Myc down-regulation is involved in proteasome inhibitor-mediated enhancement of radiot…
  4. MG132, a proteasome inhibitor, induces apoptosis in tumor cells.
  5. Combination of quercetin and tannic acid in inhibiting 26S proteasome affects S5a and 20S expression…
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Clinical Trials

Most Relevant Clinical Trials

  1. Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topi…
  2. BCD With or Without Doxycycline in Mayo Stage II-III Light Chain Amyloidosis Patients
  3. Pembrolizumab + Lenalidomide Post Autologous Stem Cell Transplant (ASCT) in High-risk Multiple Myelo…
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