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QuickView for ataxin-2 (gene)


Body Atlas

Most Correlated Tissues

  1. Whole brain
  2. Smooth muscle
  3. Cingulate cortex
  4. Prefrontal cortex
  5. Adrenal gland
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Disease Atlas

Most Correlated Diseases

  1. Disease caused by parasite
  2. Disease due to Trypanosomatidae
  3. Spinocerebellar ataxia
  4. COVID-19
  5. Parkinson's disease
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Pharmaco Atlas

Most Correlated Compounds

  1. Ethylene Dibromide
  2. Coffee
  3. trabectedin
  4. tadalafil
  5. Fish Oils
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. hsa-miR-365a-3p
  2. unc-5
  3. CG9573
  4. ATXN2
  5. Ppp1r15a
Explore Knockdown Atlas Results

Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. Ataxin-2 sequesters Raptor into aggregates and impairs cellular mTORC1 signaling.
  2. The polyglutamine protein ATXN2: from its molecular functions to its involvement in disease.
  3. Clinical features, disease progression, and nuclear imaging in ATXN2-related parkinsonism in a longi…
  4. ATXN2 is a target of N-terminal proteolysis.
  5. Abnormal open states patterns in the ATXN2 DNA sequence depends on the CAG repeats length.
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Clinical Trials

Most Relevant Clinical Trials

  1. A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Particip…
  2. Safety and Tolerability of Lithium in Spinocerebellar Ataxia 2 (SCA2)
  3. Identification of Biomarkers in Spinocerebellar Ataxia 3
  4. Clinical Trial Readiness for SCA1 and SCA3
  5. A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3
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