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QuickView for bisindolylmaleimide I (compound)


Genetic Markers

Most Correlated Genes

  1. COL13A1
  2. ETV4
  3. APLNR
  4. MCM10
  5. RRM2
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Pathway Enrichment

Most Correlated Biogroups

  1. DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP
  2. FISCHER_DREAM_TARGETS
  3. KOBAYASHI_EGFR_SIGNALING_24HR_DN
  4. GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
  5. KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
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Curated Studies

Most Correlated Studies

  1. Neural 3D tissue constructs from H1 ESC-derived precursor cells treated with neurotoxic chemicals
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Literature

Most Relevant Literature

  1. Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF 109203X) on delayed rectif…
  2. Bisindoylmaleimide I suppresses adipocyte differentiation through stabilization of intracellular bet…
  3. 6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isofo…
  4. The tramadol metabolite O-desmethyl tramadol inhibits substance P-receptor functions expressed in Xe…
  5. PKC-dependent inhibition of CA2+-dependent exocytosis from astrocytes.
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Clinical Trials

Most Relevant Clinical Trials

  1. A Phase I Trial of Enzastaurin (LY317615) in Combination With Carboplatin in Adults With Recurrent G…
  2. Study to Assess Enzastaurin + R-CHOP in Subjects With DLBCL With the Genomic Biomarker DGM1™
  3. Enzastaurin to Treat Recurrent Brain Tumor
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