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mitogen-activated protein kinase kinase 1
(compound)
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General Info
Genetic Markers
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Curated Studies
Most Correlated Studies
Mitogen-activated protein kinase kinase 4 (MKK4) knockdown in lung cancer cell line 393P
Antitumor efficacy of GDC-0879 involving BRAF mutational status
Acute monocytic leukemia (AML) THP-1 cells HIV gp120 or LPS stimulated following SB203580 treatment
Primary macrophages infected with HIV-1 or control for 2,4, or 7d
HEK cells overexpressing kinase dead and WT GRK2 after in vivo expansion and reculturing
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Literature
Most Relevant Literature
Histiocytic neoplasm subtypes differ in their MAP2K1 mutational type.
Sclerosing melanocytic tumors with MAP2K1 in-frame deletions and copy number gains in 15q: A distinc…
Arteriovenous malformation Map2k1 mutation affects vasculogenesis.
Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour ce…
Clinical, Morphologic, and Molecular Features of Benign and Intermediate-grade Melanocytic Tumors Wi…
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Clinical Trials
Most Relevant Clinical Trials
Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in…
A Multicentre, Open Label, Phase 1 Trial in Japan of the Mitogen Activated Protein Extracellular Sig…
Topical Mitogenic-Activated Protein Kinase (MAPK) Inhibition in Rosacea
p38 Mitogen−Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma
Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With…
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