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DNMT1
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NextBio Summary
General Info
Body Atlas
Most Correlated Tissues
T Lymphocyte (regulatory) of peripheral blood
Hematopoietic stem cell of bone marrow
Natural killer cell of peripheral blood
Thymus gland
T Lymphocyte (CD4+) of peripheral blood
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Disease Atlas
Most Correlated Diseases
Systemic inflammatory response syndrome
Ataxia-telangiectasia syndrome
Wegener's granulomatosis
Measles
Anomaly of chromosome pair 13
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Pharmaco Atlas
Most Correlated Compounds
torsemide
Tocainide
Amlodipine
Sulfadoxine
Ciprofloxacin
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Knockdown Atlas
Most Correlated Gene Perturbations
hsa-miR-365a-3p
Dnmt1
MCPH1
PRPH2
BP1
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Curated Studies
Most Correlated Studies
Hepatic progenitor HepaRG cells treated with compounds that cause liver injury
Multiple myeloma MM.1S cells with HDAC3 or DNMT1 shRNA knockdown
Prostate cancers derived by conditional (PB-Cre) manipulation of PTEN, TP53, MYC or ERG genes
Breast cancer MDA-MB-231 and ovarian cancer SK-OV-3 cell lines overexpressing miR-365-3p
The Cancer Genome Atlas (TCGA) - somatic mutations in cutaneous melanoma
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Literature
Most Relevant Literature
Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1.
Exosomal DNMT1 mediates cisplatin resistance in ovarian cancer.
In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltrans…
Reciprocal Regulation Between miR-148a/152 and DNA Methyltransferase 1 Is Associated with Hyperhomoc…
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation.
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Clinical Trials
Most Relevant Clinical Trials
p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Pancreatic Cancer
Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Ca…
Azacitidine and Lintuzumab in Treating Patients With Previously Untreated Myelodysplastic Syndromes
NTX-301 in MDS/AML
Analysis of DNA Methylation in Spondyloarthritis
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