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H3 1
Summary
General Info
Curated Studies
Most Correlated Studies
Neurons and astrocytes with manipulated H3.1/H3.3 gene expression and KCl stimulation
Dermal fibroblasts overexpressing wildtype or mutant histone H3.1 or with EZH2 shRNA knockdown
Broad Connectivity Map (CMAP 2.0) compound database
Mutations in histone H3.3 in pediatric glioblastoma
Embryonic stem cells with H3.3A shRNA knockdown and H3.3B induced knockout
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Literature
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Polyadenylation of canonical histone H3.1 in carcinogenesis.
Mitotic inheritance of genetic and epigenetic information via the histone H3.1 variant.
The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.
The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.
Citrullination of extracellular histone H3.1 reduces antibacterial activity and exacerbates its prot…
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Clinical Trials
Most Relevant Clinical Trials
H3: Healthy Minds, Healthy Children, Healthy Chicago Project Evaluation
Safety Study of MGD009 in B7-H3-expressing Tumors
ONC201 in Pediatric H3 K27M Gliomas
Pilot Study of B7-H3 CAR-T in Treating Patients With Recurrent and Refractory Glioblastoma
Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors
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