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Metolazone
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
SLC12A1
ANP32A
PRKAR1A
CSGALNACT2
ADAM9
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Pathway Enrichment
Most Correlated Biogroups
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN
GCNP_SHH_UP_LATE.V1_UP
GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_DN
ODONNELL_TFRC_TARGETS_DN
GSE14308_TH2_VS_NAIVE_CD4_TCELL_DN
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Curated Studies
Most Correlated Studies
Broad Connectivity Map (CMAP 2.0) compound database
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
Drug target sets for approved compounds
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Literature
Most Relevant Literature
An improved LC-MS/MS method for quantitative determination of metolazone in human plasma and its app…
Comparative characterization of Na+ transport in Cyprinodon variegatus variegatus and Cyprinodon var…
The evaluation of the diuretic action of parenteral formulations of metolazone.
Determination of metolazone in human blood by liquid chromatography with electrospray ionization tan…
Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failur…
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Clinical Trials
Most Relevant Clinical Trials
Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure
Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing
A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Hear…
Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure (MELT-HF)--A Single Center …
Fasting Study of Metolazone Tablets 5 mg and Zaroloxyn® Tablets 5 mg
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