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TSC2
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Rapamycin-insensitive up-regulation of MMP2 and other genes in TSC2- deficient LAM-like cells
L1000 CMAP Prostate cancer PC3 cells with gene overexpression perturbations (2 of 2)
L1000 CMAP Prostate cancer PC3 cells with gene overexpression perturbations (1 of 2)
L1000 CMAP - Hepatocellular carcinoma Hep G2 cells with shRNA-mediated gene knockdown (2 of 2)
L1000 CMAP Lung cancer NCI-H1299 cells with gene overexpression perturbations
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Literature
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Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status.
Generation of a TSC2 knockout embryonic stem cell line by CRISPR/Cas9 editing.
The role of TSC1 and TSC2 proteins in neuronal axons.
Non-canonical functions of a mutant TSC2 protein in mitotic division.
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in…
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Everolimus for Cancer With TSC1 or TSC2 Mutation
Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Altera…
Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/o…
Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutation…
A Study of Sirolimus for Injection (Albumin-bound) in Patients With Advanced Solid Tumors
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