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QuickView for Topoisomerase II (gene)


Body Atlas

Most Correlated Tissues

  1. Hematopoietic stem cell of bone marrow
  2. Granulocyte-macrophage progenitor cell of bone marrow
  3. Basophil of peripheral blood
  4. T Lymphocyte (regulatory) of peripheral blood
  5. Natural killer cell of peripheral blood
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Disease Atlas

Most Correlated Diseases

  1. Multiple-resistant Staphylococcus aureus infection
  2. Thyroid eye disease
  3. Disorder of eye
  4. Cerebral palsy
  5. Ataxia-telangiectasia syndrome
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Pharmaco Atlas

Most Correlated Compounds

  1. Lead
  2. famciclovir
  3. 2-(4-(pyridin-4-yl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl)phenoxymethyl)quinoline succinic acid
  4. IL8 protein, human
  5. Ephrin-A4
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. tkv
  2. Ptger4
  3. PLEKHG6
  4. RNMT
  5. STK38
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. Mapping catalytically engaged TOP2B in neurons reveals the principles of topoisomerase action within…
  2. TOP2B's contributions to transcription.
  3. Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B…
  4. To Break or Not to Break: The Role of TOP2B in Transcription.
  5. XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.
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Clinical Trials

Most Relevant Clinical Trials

  1. Topoisomerase II Alpha Gene Amplification and Protein Overexpression Predicting Efficacy of Epirubic…
  2. Epirubicin or Not in Patients With TOP2A (Topoisomerase (DNA) II Alpha (170kD)) Normal Early Breast …
  3. Clinical Benefit of Topoisomerase Downregulation
  4. Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin - Etoposide /Carboplatin in Extensive Smal…
  5. Epirubicin in Treating Women Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Breast C…
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