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Trovafloxacin
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
SPAG4
HES1
B2M
SLC22A7
CYP3A4
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Pathway Enrichment
Most Correlated Biogroups
FISCHER_DREAM_TARGETS
heterocyclic compound binding
organic cyclic compound binding
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Most Correlated Studies
HCC Hep G2 cells with nimesulide, nefazodone, trovafloxacin, aspirin, buspirone or levofloxacin
Liver tissues from rats after treatment with different compounds
Hepatic progenitor HepaRG cells treated with compounds that cause liver injury
Drug Matrix In Vivo Toxicogenomic Study - Rat Liver [Codelink]
Comparison of primary human hepatocytes to Hep G2 cells treated with fluoroquinolone compounds
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Literature
Most Relevant Literature
Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiolo…
Trovafloxacin drives inflammation-associated drug-induced adverse hepatic reaction by changing macro…
TNFα enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy.
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced…
Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine…
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Clinical Trials
Most Relevant Clinical Trials
Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia
Maintenance Dovitinib for Colorectal and Pancreas Cancer
Phase IIa Trial to Determine the Effects of Bardoxolone Methyl on Renal Function in Patients With Di…
Interferon-beta1a (AVONEX) Treatment of Ulcerative Colitis
Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Diabetes and Ch…
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