QuickView for UGGT (gene)

1. Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mam…
2. R1526 residue in arginine/proinsulin binding domain of UGGT1 is involved in proinsulin binding.
3. The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I.
4. Glycan dependent refolding activity of ER glucosyltransferase (UGGT).
5. UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.

There were no clinical trials for UGGT