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crizotinib
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Summary
General Info
Genetic Markers
Most Correlated Genes
HAL
TNFAIP3
MMP1
SERPINA3
PAEP
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Pathway Enrichment
Most Correlated Biogroups
cytosol
organic cyclic compound binding
heterocyclic compound binding
nucleoplasm
organic cyclic compound metabolic process
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Curated Studies
Most Correlated Studies
Multiple cancer cell lines treated with 32 kinase inhibitors
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Hepatocellular carcinoma HEPG2 cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
Crizotinib: A comprehensive profile.
Anticancer effect of crizotinib on osteosarcoma cells by targeting c-Met signaling pathway.
Decrease in estimated glomerular filtration rates in non-small cell lung cancer patients treated wit…
Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp…
Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells.
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Clinical Trials
Most Relevant Clinical Trials
Crizotinib Continuation Clinical Study
Dasatinib and Crizotinib in Advanced Cancer
Pazopanib or Pemetrexed and Crizotinib in Advanced Cancer
Long Term Safety Observation of Crizotinib in Chinese NSCLC Population
Drug Drug Interaction Study Of Crizotinib With Esomeprazole.
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