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gsk690693
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Summary
General Info
Genetic Markers
Most Correlated Genes
SLC26A2
MAL
RBP4
AGR2
TNFAIP3
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Pathway Enrichment
Most Correlated Biogroups
regulation of nitrogen compound metabolic process
cell periphery
organic cyclic compound binding
heterocyclic compound binding
cytosol
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Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Hepatocellular carcinoma HEPG2 cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
L1000 CMAP - Breast adenocarcinoma SKBR3 cells treated with small molecule perturbagens
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Literature
Most Relevant Literature
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway.
Akt dependent adult hippocampal neurogenesis regulates the behavioral improvement of treadmill runni…
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K…
Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer…
A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific in…
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Clinical Trials
Most Relevant Clinical Trials
Study to Investigate AKT Inhibitor GSK690693 in Subjects With Relapsed or Refractory Hematologic Mal…
Open-label Study to Investigate the Safety, Tolerability, PK, and Pharmacodynamics of the AKT Inhibi…
Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Change…
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