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histamine agonists
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
HRH2
SERPINB2
FOS
HRH1
SEMA5A
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Pathway Enrichment
Most Correlated Biogroups
HALLMARK_TNFA_SIGNALING_VIA_NFKB
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN
organic cyclic compound metabolic process
heterocycle metabolic process
response to organic substance
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Curated Studies
Most Correlated Studies
Human HaCaT keratinocytes stimulated with histamine
Macrophages derived from PBMCs of healthy donors exposed to different allergens
APL PLB-985 cells with WT or NOX2 KO and treated with histamine dihydrochloride or DMSO
Placental explants from normal term pregnancies treated with or without histamine and oxygen
Drug target sets for approved compounds
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Literature
Most Relevant Literature
Overdose of the histamine H₃ inverse agonist pitolisant increases thermal pain thresholds.
The histamine H₃-receptor inverse agonist pitolisant improves fear memory in mice.
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective h…
4,5-dihydropyridazin-3-one derivatives as histamine H₃ receptor inverse agonists.
Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor invers…
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Clinical Trials
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A Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety …
Fexofenadine HCl 180 mg, Desloratadine 5 mg and Placebo in Suppression of Wheal and Flare Induced by…
Mechanisms of Adverse Effects of Long-Acting Beta-Agonists in Asthma
Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itc…
TransMEM Gas Exchange -- Project 1, Aim 2
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