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mecamylamine
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Summary
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Genetic Markers
Most Correlated Genes
CHRNA2
HMGCS1
DNAAF1
LMNB1
CA5BP1
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Pathway Enrichment
Most Correlated Biogroups
GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_DN
GSE14350_TREG_VS_TEFF_DN
GSE23568_ID3_KO_VS_WT_CD8_TCELL_UP
GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_1H_UP
AMIT_EGF_RESPONSE_480_HELA
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Curated Studies
Most Correlated Studies
Drug target sets for approved compounds
Broad Connectivity Map (CMAP 2.0) compound database
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
Mecamylamine elicits withdrawal-like signs in rats following a single dose of nicotine.
Placebo-controlled pilot trial of mecamylamine for treatment of autism spectrum disorders.
Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Interactions between mecamylamine and alcohol in Long-Evans rats: flash-evoked potentials, body temp…
Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: …
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Clinical Trials
Most Relevant Clinical Trials
Mecamylamine for Autonomic Dysreflexia Prophylaxis
Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence
Study of the Effects of Mecamylamine and Varenicline in Schizophrenia
Placebo-Controlled Pilot Trial of Mecamylamine for Treatment of Autism Spectrum Disorders
Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients
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