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QuickView for mln8237 (compound)


Genetic Markers

Most Correlated Genes

  1. PRPH
  2. MYBL2
  3. MAL
  4. H19
  5. Fndc3c1
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Pathway Enrichment

Most Correlated Biogroups

  1. FISCHER_DREAM_TARGETS
  2. GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN
  3. organic cyclic compound metabolic process
  4. heterocycle metabolic process
  5. cellular aromatic compound metabolic process
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Curated Studies

Most Correlated Studies

  1. Neuroblastoma mNB-A1 cell line treated with BRD4 or AURKA inhibitors
  2. Lung cancer KRAS-mutant A549 cells treated with aurora kinase inhibitors VX680, AZD1152, and MLN8237
  3. Pancreatic ductal cancer PANC-1 cells treated with chaetocin or MLN 8237 alone or in combination
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Literature

Most Relevant Literature

  1. Differentiation therapy for murine myelofibrosis model with MLN8237 loaded low-density lipoproteins.
  2. Aurora kinase a inhibitor MLN8237 suppresses pancreatic cancer growth.
  3. Phase 1 study of alisertib (MLN8237) and weekly irinotecan in adults with advanced solid tumors.
  4. A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma.
  5. Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigatio…
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Clinical Trials

Most Relevant Clinical Trials

  1. Study of MLN8237 in Combination With Irinotecan and Temozolomide
  2. MLN8237 for a Subject With Adenocarcinoma of the Prostate
  3. MLN8237 in Head and Neck Cancer
  4. MLN8237 to Treat Children With Relapsed/Refractory Solid Tumors
  5. A Phase II Trial of MLN8237 in Patients With Metastatic Castrate Resistant and Neuroendocrine Prosta…
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