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pde4 inhibitors
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NextBio Summary
General Info
Genetic Markers
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SDHD
CXCL1
CDK1
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response to organic substance
response to organic cyclic compound
response to nitrogen compound
response to hormone
regulation of nitrogen compound metabolic process
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Cortical neurons exposed to excitotoxic NMDA and potentially neuroprotective compounds
Bronchus epithelial BEAS-2B cells with temporal treatment of GS-5759 or indacaterol and GSK256066
Rolipram treated B-CLL, normal B, and normal T cells
Broad Connectivity Map (CMAP 2.0) compound database
Livers of rat exposed to variety of hepatotoxic compounds
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Literature
Most Relevant Literature
The effect and associated mechanism of action of phosphodiesterase 4 (PDE4) inhibitor on CD4+ lympho…
Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human…
Novel imidazophenoxazine-4-sulfonamides: their synthesis and evaluation as potential inhibitors of P…
Tetomilast: new promise for phosphodiesterase-4 inhibitors?
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PK…
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Most Relevant Clinical Trials
A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in…
Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea
A Proof-of-principle Study of Oral Treatment of Non-alcoholic Steatohepatitis With a Novel PDE4 Inhi…
Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 …
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients
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