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QuickView for plx4720 (compound)


Genetic Markers

Most Correlated Genes

  1. SPRY4
  2. DUSP6
  3. UCN2
  4. HS3ST1
  5. BMF
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Pathway Enrichment

Most Correlated Biogroups

  1. regulation of nitrogen compound metabolic process
  2. ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY
  3. KOBAYASHI_EGFR_SIGNALING_24HR_DN
  4. CHICAS_RB1_TARGETS_SENESCENT
  5. LEE_BMP2_TARGETS_UP
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Curated Studies

Most Correlated Studies

  1. Colon cancer cell lines with acquired resistance to BRAF inhibitor PLX4720 and parental lines
  2. Apollon knockdown in a melanoma cell line treated with fotemustine, PLX4720 or PD0325901
  3. Melanoma-associated fibroblasts treated with PLX4720
  4. Lung adenocarcinoma cells with YAP1 shRNA and treated with MEK or BRAF inhibitor
  5. Melanoma A375 cells (BRAF V600E) with SOX10 ko or SOX10-deficient BRAFi + MEKi resistant cells
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Literature

Most Relevant Literature

  1. Downregulation of lncRNA TSLNC8 promotes melanoma resistance to BRAF inhibitor PLX4720 through bindi…
  2. BRAF paradox breakers PLX8394, PLX7904 are more effective against BRAFV600Ε CRC cells compared with …
  3. A Combinatorial Strategy for Targeting BRAF V600E-Mutant Cancers with BRAFV600E Inhibitor (PLX4720) …
  4. The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a…
  5. SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cel…
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Clinical Trials

Most Relevant Clinical Trials

  1. Biomarker Study of PDR001 in Combination With MCS110 in Gastric Cancer
Explore Clinical Trials Results
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