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QuickView for synuclein (compound)


Genetic Markers

Most Correlated Genes

  1. CPA4
  2. IGFBP3
  3. TAGLN
  4. A2M
  5. CYR61
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Pathway Enrichment

Most Correlated Biogroups

  1. GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
  2. FISCHER_DREAM_TARGETS
  3. GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_UP
  4. DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP
  5. PILON_KLF1_TARGETS_DN
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Curated Studies

Most Correlated Studies

  1. Microglia treated with conditioned media from SH-SY5Y cells overexpressing α-Synuclein
  2. Dopaminergic neurons treated with de novo, PD-amplified or MSA-amplified α-synuclein fibrils
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Literature

Most Relevant Literature

  1. Fish Synucleins: An Update.
  2. Host oligodendrogliopathy and ɑ-synuclein strains dictate disease severity in multiple system atroph…
  3. Dementia with Lewy bodies-associated ß-synuclein mutations V70M and P123H cause mutation-specific ne…
  4. Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181.
  5. Genetics of synucleins in neurodegenerative diseases.
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Clinical Trials

Most Relevant Clinical Trials

  1. Systemic Synuclein Sampling Study (S4)
  2. Optimization of Morphomer-based Alpha-synuclein PET Tracers
  3. Oligomeric Alpha-synuclein in Multiple System Atrophy
  4. Proof of Mechanism Study to Evaluate Binding of Alfa-synuclein
  5. Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain
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