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wdr77
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Prostate cancer 22Rv1 cells with Dox-inducible shRNA-mediated PRMT5, MEP50, and CLNS1A knockdown
Breast adenocarcinoma MD-MBA-231 cells with shRNA knockdown of both WDR77 and PRMT5
Lung cancer A549 cells with PRMT5 or WDR77 shRNA knockdown
Prostate cancer LNCaP and lung cancer A549 cell lines with PRMT5 or WDR77 shRNA knockdown
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Literature
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WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver.
Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer.
Methylosome protein 50 associates with the purinergic receptor P2X5 and is involved in osteoclast ma…
Mutations in bdcA and valS Correlate with Quinolone Resistance in Wastewater Escherichia coli.
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