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QuickView for negative regulation of catalytic activity (biogroup)


Body Atlas

Most Correlated Tissues

  1. Lung
  2. Omental adipose tissue
  3. Salivary gland
  4. Adipose tissue subcutaneous
  5. Adipose tissue
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Disease Atlas

Most Correlated Diseases

  1. Alpha-1-antitrypsin deficiency
  2. Disorder of digestive system
  3. Disease due to Orthopoxvirus
  4. Lymphedema
  5. Perforation of tympanic membrane
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Pharmaco Atlas

Most Correlated Compounds

  1. ARQ 197
  2. FR 180204
  3. KW 2449
  4. CGP 60474
  5. N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. ANKRD2
  2. TLK2
  3. FUBP3
  4. NOP2
  5. DIDO1
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Curated Studies

Most Correlated Studies

  1. Neuroblastoma SKNDZ cells overexpressing MIR-125-B2
  2. L1000 CMAP - Prostate cancer PC3.101 cells with CRISPR-targeted gene knockouts
  3. L1000 CMAP - Embryonic stem HUES3 cells treated with small molecule perturbagens
  4. Neural development of iPSCs derived from Autistic patients with BCKD-kinase mutations
  5. Reprogramming of fibroblasts into embryonic Sertoli-like cells
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Literature

Most Relevant Literature

  1. Direct binding of plectin to Fer kinase and negative regulation of its catalytic activity.
  2. Regulation of Sos activity by intramolecular interactions.
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Clinical Trials

Most Relevant Clinical Trials

  1. Taselisib and Enzalutamide in Treating Patients With Androgen Receptor Positive Triple-Negative Meta…
  2. Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease
  3. PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS
  4. Iron Supplementation and Eccentric Exercise
  5. Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects
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