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QuickView for regulation of MAP kinase activity (biogroup)


Body Atlas

Most Correlated Tissues

  1. Lung
  2. Pituitary gland
  3. Kidney medulla
  4. Kidney cortex
  5. Occipital lobe
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Disease Atlas

Most Correlated Diseases

  1. Alpha-1-antitrypsin deficiency
  2. Disorder of digestive system
  3. Disease due to Orthopoxvirus
  4. Listeriosis
  5. Fungal keratitis
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Pharmaco Atlas

Most Correlated Compounds

  1. ARQ 197
  2. FR 180204
  3. KW 2449
  4. CGP 60474
  5. N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. ANKRD2
  2. TLK2
  3. FUBP3
  4. NOP2
  5. AKT2
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Curated Studies

Most Correlated Studies

  1. Neuroblastoma SKNDZ cells overexpressing MIR-125-B2
  2. L1000 CMAP - Prostate cancer PC3.101 cells with CRISPR-targeted gene knockouts
  3. L1000 CMAP - Colorectal cancer HT29.311 cells with CRISPR-targeted gene knockouts
  4. L1000 CMAP - Motor neuron MNEU.E cells treated with small molecule perturbagens
  5. L1000 CMAP - Embryonic stem HUES3 cells treated with small molecule perturbagens
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Literature

Most Relevant Literature

  1. Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast phero…
  2. Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity.
  3. Protein phosphatases and the regulation of MAP kinase activity.
  4. Regulation of MAP kinase pathway activity in vivo in human skeletal muscle.
  5. Differential regulation of MAP kinase activity by corticotropin-releasing hormone in normal and neop…
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Clinical Trials

Most Relevant Clinical Trials

  1. Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With…
  2. Nutritional Regulation of Wound Inflammation: Part III
  3. A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and…
  4. Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced …
  5. BEP Study Phase I (Bevacizumab, Everolimus, Panitumumab)
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