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BRCA1-BARD1 complex
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Kidney medulla
Bone marrow
Kidney cortex
Thymus gland
Omental adipose tissue
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Disease Atlas
Most Correlated Diseases
Vesicular stomatitis Indiana virus disease
Injury of heart
Salmonella infection
Viral infections of the central nervous system
Meningitis
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Pharmaco Atlas
Most Correlated Compounds
PHA 739358
PF 3758309
RAF265
oltipraz
Phorbol Esters
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Knockdown Atlas
Most Correlated Gene Perturbations
MIR30A
TMEM11
RPS6
HIC1
NOP2
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Curated Studies
Most Correlated Studies
NSCLC PC9 cells selected for gefitinib sensitivity or resistance treated with EGF and gefitinib
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
OMIM - Malignant neoplasms
L1000 CMAP Breast cancer MCF7 cells with gene overexpression perturbations
L1000 CMAP - Non-small cell lung cancer A549.311 cells with CRISPR targeted gene knockouts
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Literature
Most Relevant Literature
The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination.
Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.
Molecular dynamics simulations reveal the effect of mutations in the RING domains of BRCA1-BARD1 com…
BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.
BRCA1/BARD1 complex interacts with steroidogenic factor 1--A potential mechanism for regulation of a…
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Clinical Trials
Most Relevant Clinical Trials
Phase II Study of Olaparib and Pembrolizumab in Advanced Melanoma With Homologous Recombination (HR)…
Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutati…
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