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V(D)J recombination
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Thymus gland
Tonsil
Lymph nodes
Heart
Placenta
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Disease Atlas
Most Correlated Diseases
Social environment related disease
Vesicular stomatitis Indiana virus disease
Alpha-1-antitrypsin deficiency
Cryptococcosis
Infection due to Staphylococcus aureus
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Pharmaco Atlas
Most Correlated Compounds
AST-1306
OTS-167
MK 1775
VX-745
HG-9-91-01
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Knockdown Atlas
Most Correlated Gene Perturbations
PTPN6
HTRA1
POLH
LCP2
MIR122
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Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Umbilical vein endothelial HUVEC cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7.311 cells with CRISPR-induced gene knockouts
L1000 CMAP - Cervical cancer HELA.311 cells with CRISPR induced gene knockouts
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
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Literature
Most Relevant Literature
The role of CTCF in regulating V(D)J recombination.
RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.
Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombin…
Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and non…
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Clinical Trials
Most Relevant Clinical Trials
Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioe…
Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage …
Efficacy and Safety of Activated Recombinant Human Factor VII in Severely Injured Trauma Patients
Recombinant Human Thrombopoietin (rhTPO) Combining Rituximab Versus High-dose Dexamethasone for Init…
Immune Responses in Patients Treated With Raltegravir
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