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intra-S DNA damage checkpoint
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General Info
Body Atlas
Most Correlated Tissues
Testes
B lymphocyte (naive) of spleen
T Lymphocyte (regulatory) of peripheral blood
Tonsil
T Lymphocyte (CD4+) of peripheral blood
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Disease Atlas
Most Correlated Diseases
Vesicular stomatitis Indiana virus disease
Pyloric ulcer
Rhinitis
Zika virus disease
Caseating tuberculoid granuloma
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Pharmaco Atlas
Most Correlated Compounds
Acetamides
combretastatin A-4
Gramicidin
PHA 793887
Floxuridine
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Knockdown Atlas
Most Correlated Gene Perturbations
MIR887
Idd1
Idd5
RPS6
MAPK13
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Curated Studies
Most Correlated Studies
Suppression of breast tumor growth and metastasis by an engineered transcription factor
DNA integrity network in Saccharomyces cerevisiae
Calu-3 lung adenocarcinoma cells infected with wildtype and mutant SARS virus
L1000 CMAP - Lung cancer A549 cells treated with ligand perturbagens
Embryonic stem cell, induced-pluripotent stem cell and fibroblast expression profiles
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Literature
Most Relevant Literature
A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra…
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Association of common PALB2 polymorphisms with breast cancer risk: a case-control study.
Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characteriz…
Checking on DNA damage in S phase.
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Clinical Trials
Most Relevant Clinical Trials
Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With M…
Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors
Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients
Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harbori…
Nivolumab in Combination With Talazoparib in Melanoma and Mutations in BRCA or BRCA-ness Genes
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