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(e.g. rs2300478, PDX1, Fatty acid metabolic process, Diabetes mellitus, Leukocyte, Nosology)
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QuickView for thiamine pyrophosphate binding (biogroup)


Body Atlas

Most Correlated Tissues

  1. Kidney cortex
  2. Liver
  3. Kidney medulla
  4. Kidney
  5. Thyroid gland
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Disease Atlas

Most Correlated Diseases

  1. Deficiency of oxoglutarate dehydrogenase (lipoamide)
  2. Intestinal infectious disease
  3. Liver fluke infection
  4. Liver transplant disorder
  5. Hutchinson-Gilford syndrome
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Pharmaco Atlas

Most Correlated Compounds

  1. ubiquinol
  2. pronamide
  3. PD 184352
  4. TO-901317
  5. GDC 0879
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. PAAF1
  2. CAMK1
  3. NOP2
  4. MAD2L1
  5. TOR1
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Curated Studies

Most Correlated Studies

  1. Transcriptomic analysis of eleven organs of male and female rats at four developmental stages
  2. Yeast treated with 15 uM Cycloheximide for 2 hr
  3. L1000 CMAP Breast cancer MCF7 cells with gene overexpression perturbations
  4. Tumor phenotype of clear cell renal cell carcinoma (CRCC)
  5. Clear cell renal cell carcinoma and normal adjacent tissue expression profiles
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Literature

Most Relevant Literature

  1. Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae.
  2. Riboswitch-mediated control of gene expression in eukaryotes.
  3. Switching the light on plant riboswitches.
  4. Molecular basis of gene regulation by the THI-box riboswitch.
  5. The THI-box riboswitch, or how RNA binds thiamin pyrophosphate.
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Clinical Trials

Most Relevant Clinical Trials

  1. Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.
  2. Multi-Nutrient Supplementation as a Therapeutic Intervention in Ischaemic Stroke
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