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BRCA1-A complex
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Thymus gland
Subthalamic nucleus
Stomach cardiac
Nodose nucleus
Testes
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Disease Atlas
Most Correlated Diseases
Pyloric ulcer
Vesicular stomatitis Indiana virus disease
Alpha-1-antitrypsin deficiency
Injury of integument
Disorder of uterus
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Pharmaco Atlas
Most Correlated Compounds
((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)
bromohydrin pyrophosphate
AZD1480
Glesatinib
MK 1775
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Knockdown Atlas
Most Correlated Gene Perturbations
hsa-miR-31-5p
AURKB
RNR1
GM2A
DIDO1
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Curated Studies
Most Correlated Studies
NSCLC PC9 cells selected for gefitinib sensitivity or resistance treated with EGF and gefitinib
L1000 CMAP - Breast adenocarcinoma SKBR3 cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast carcinoma BT20 cells treated with small molecule perturbagens
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Literature
Most Relevant Literature
Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivit…
Molecular dynamics simulations reveal the effect of mutations in the RING domains of BRCA1-BARD1 com…
Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.
Mislocalization of BRCA1-complex due to ABRAXAS Arg361Gln mutation.
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Clinical Trials
Most Relevant Clinical Trials
Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing
Gedatolisib Plus Talazoparib in Advanced Triple Negative or BRCA1/2 Positive, HER2 Negative Breast C…
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Ris…
Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or…
Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in …
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