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dihydroorotate dehydrogenase activity
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Liver
Pericardium
Heart atrium
Cecum
Stomach cardiac
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Disease Atlas
Most Correlated Diseases
Hepatocellular dysplasia
Acute hepatic failure
Hepatic failure
Effects of reduced temperature
Effects of heat
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Pharmaco Atlas
Most Correlated Compounds
lactofen
Salts
4-anisaldehyde
allicin
5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one
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Knockdown Atlas
Most Correlated Gene Perturbations
SUC2
mec-3
His1:CG31617
BRD4
COG7
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Curated Studies
Most Correlated Studies
Drug target sets for approved compounds
L1000 CMAP Breast cancer MCF7 cells with gene overexpression perturbations
Drosophila life cycle - embryo, larva, pupa and adult stages
L1000 CMAP - Prostate carcinoma VCaP cells treated with ligand perturbagens
Breast adenocarcinoma MCF7 cells treated with various environmental chemicals
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Literature
Most Relevant Literature
Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydroge…
Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide.
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Clinical Trials
Most Relevant Clinical Trials
A Study to Investigate BAY2402234, a Dihydroorotate Dehydrogenase (DHODH) Inhibitor, in Myeloid Mali…
CRISIS2: A Phase 2 Study of the Safety and Antiviral Activity of Brequinar in Non-hospitalized Pts W…
A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma
A Study of JNJ-74856665 in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrom…
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