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thymidylate synthase activity
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Summary
General Info
Body Atlas
Most Correlated Tissues
Hematopoietic stem cell of bone marrow
Granulocyte-macrophage progenitor cell of bone marrow
Thymus gland
Bone marrow
Fetal liver
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Disease Atlas
Most Correlated Diseases
Rhinitis
Bacterial septicemia
Anomaly of chromosome pair 12
Spinocerebellar ataxia
Prematurity of fetus
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Pharmaco Atlas
Most Correlated Compounds
raltitrexed
Floxuridine
pemetrexed
Leucovorin
5-(6)-carboxyfluorescein diacetate succinimidyl ester
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Knockdown Atlas
Most Correlated Gene Perturbations
MIR103A2
TDP2
ING2
CASP4
MIRLET7F1
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Curated Studies
Most Correlated Studies
L1000 CMAP Prostate cancer PC3 cells with gene overexpression perturbations (1 of 2)
L1000 CMAP Osteosarcoma U-2 OS cells with gene overexpression perturbations
L1000 CMAP Prostate cancer PC3 cells with gene overexpression perturbations (2 of 2)
Drug target sets for approved compounds
L1000 CMAP - Hepatocellular carcinoma Hep G2 cells with shRNA-mediated gene knockdown (2 of 2)
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Literature
Most Relevant Literature
Salmonella typhimurium thyA mutants fail to grow intracellularly in vitro and are attenuated in mice…
Synergistic antitumor effect of S-1 and HER2-targeting agents in gastric cancer with HER2 amplificat…
Oxidase activity of a flavin-dependent thymidylate synthase.
Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aur…
Thymidylate synthase protein expression and activity are related to the cell proliferation rate in h…
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Clinical Trials
Most Relevant Clinical Trials
Capecitabine as Second-Line Therapy in Treating Patients With Stage IV Pancreatic Cancer Who Have th…
Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase
Pemetrexed/Cisplatin Versus Gemcitabine/Cisplatin According to Thymidylate Synthase Expression
NB1011 Administered by Continuous Infusion in Cancers That Overexpress Thymidylate Synthase (TS)
Open-label, Multicenter, Randomized Phase II Trial of Treatment With Cisplatin and Pemetrexed or Cis…
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