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X-ray structure of HIV-1 protease tethered dimer complexed to ritonavir.

Amit Das, Dharmaraj Ramachandra Rao, Madhusoodan Vijayacharya Hosur

Solid State Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai-400085, India.

Protein and peptide letters 2007


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    We report here the 2.5A structure of HIV-1 protease tethered-dimer ritonavir complex. The inhibitor bound in the active site has different conformations in the two orientations. There is only one hydrogen bond between the inhibitor and the enzyme. The conserved flap-water is not found in the present complex.

    Citation

    Amit Das, Dharmaraj Ramachandra Rao, Madhusoodan Vijayacharya Hosur. X-ray structure of HIV-1 protease tethered dimer complexed to ritonavir. Protein and peptide letters. 2007;14(6):565-8

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    PMID: 17627597

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