N2-acetylphenelzine: effects on rat brain GABA, alanine and biogenic amines.

K F McKenna, G B Baker, R T Coutts

PMHAC Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Canada.

Naunyn-Schmiedeberg's archives of pharmacology 1991 May

filter terms:

The neurochemical properties of N2-acetylphenelzine were compared with those of phenelzine in a rat model. N2-Acetylphenelzine is a relatively potent inhibitor of monoamine oxidase-A and -B and causes increases in whole-brain levels of noradrenaline and 5-hydroxytryptamine, and decreases in homovanillic acid, 5-hydroxyindole-3-acetic acid, and 3,4-dihydroxyphenylacetic acetic after acute i.p. administration of the drug. Phenelzine is a more potent monoamine oxidase inhibitor than is N2-acetylphenelzine. The most marked difference in the profile was that N2-acetylphenelzine had no effect on whole brain levels of the amino acid neurotransmitters alanine and gamma-aminobutyric acid, whereas phenelzine caused dramatic increases. Acetylation of phenelzine at the N2 position presumably interferes with the inhibition of the transaminase enzymes for gamma-aminobutyric acid and alanine.

Citation

K F McKenna, G B Baker, R T Coutts. N2-acetylphenelzine: effects on rat brain GABA, alanine and biogenic amines. Naunyn-Schmiedeberg's archives of pharmacology. 1991 May;343(5):478-82